Zabofloxacin (DW-224a) activity against Neisseria gonorrhoeae including quinolone-resistant strains.

Jones RN, Biedenbach DJ, Ambrose PG, Wikler MA.

Zabofloxacin, a new fluoroquinolone compound (DW-224a), was tested by reference agar dilution methods against 35 strains of multiresistant Neisseria gonorrhoeae. The potency of zabofloxacin (MIC, 0.016 microg/mL) was generally comparable with azithromycin but 8-fold superior to ciprofloxacin. This novel naphthyridine should be explored as an alternative therapy for quinolone-nonsusceptible gonorrhea and Chlamydia trachomatis infections.

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