Pharmacometric Analyses

Pharmacometric analyses, which are advanced applications of pharmacokinetic-pharmacodynamic systems analysis, sits at the core of what we do at ICPD. We stress the system analysis approach because it facilitates robust, relevant models informed by our best understanding of the pertinent biology. Typical pharmacometric analyses and the tools utilized by ICPD in their conduct include:

Individual and population pharmacokinetic study design
·ADAPT, Optimal Sampling Theory, Monte Carlo simulation

Individual pharmacokinetic-pharmacodynamic model development
·ADAPT, WinNonLin®, S-ADAPT

Population pharmacokinetic-pharmacodynamic model development
·ADAPT, S-ADAPT, NONMEM®, IT2S, NPAG

Development dosing guidelines, based upon pharmacokinetic-pharmacodynamic principles
·Development and validation of optimal adaptive feedback control algorithms

Monte Carlo simulation, including clinical trial simulation, pharmacokinetic-pharmacodynamic target attainment analyses, and more.
·ADAPT
·Crystal Ball®
·S-ADAPT
·SYSTAT®/SAS®/R