Pharmacometric analyses, which are advanced applications of pharmacokinetic-pharmacodynamic systems analysis, sits at the core of what we do at ICPD. We stress the system analysis approach because it facilitates robust, relevant models informed by our best understanding of the pertinent biology. Typical pharmacometric analyses and the tools utilized by ICPD in their conduct include:
Individual and population pharmacokinetic study design
·ADAPT, Optimal Sampling Theory, Monte Carlo simulation
Individual pharmacokinetic-pharmacodynamic model development
·ADAPT, WinNonLin®, S-ADAPT
Population pharmacokinetic-pharmacodynamic model development
·ADAPT, S-ADAPT, NONMEM®, IT2S, NPAG
Development dosing guidelines, based upon pharmacokinetic-pharmacodynamic principles
·Development and validation of optimal adaptive feedback control algorithms
Monte Carlo simulation, including clinical trial simulation, pharmacokinetic-pharmacodynamic target attainment analyses, and more.
·ADAPT
·Crystal Ball®
·S-ADAPT
·SYSTAT®/SAS®/R